Samia was born in Jaffa, Palestine in 1933. She graduated from Birzeit College in 1950 and gained a BA degree from Southwestern University in Georgetown, Texas. Khoury has gained recognition as an active community member from local NGOS and the UN. She retired in 2003 from a 17 year tenure as President of Rawdat El-Zuhur, an elementary school for the lower income community in East Jerusalem. Khoury explores community life and the social and political problems facing Palestinians under occupation in her work.